×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
Reduced BRCA1 gene expression is common in the sporadic form of ovarian carcinoma .
23339184 2013
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
We found that high-grade serous ovarian carcinoma had significantly higher MIR182 (P=0.0003) and HMGA2 (P=0.04) expression, and significantly lower BRCA1 (P<0.0001) and FOXO3 (P<0.001) expression than normal controls.
22790015 2012
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
AlteredExpression
BEFREE
Low BRCA1 expression in primary sporadic ovarian carcinoma is associated with prolonged survival.
19602291 2009
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
PosttranslationalModification
BEFREE
BRCA1 promoter hypermethylation and protein expression in ovarian carcinoma --an Indian study.24385383 2014
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma .
31653147 2019
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA1 /2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma .30606148 2019
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
This study shows that BRCA1 IHC is well correlated with molecular events in ovarian carcinoma .
23232854 2013
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA-1 and BRCA-2 are tumor suppressor genes in familial breast-ovarian carcinoma syndrome.11550149 2001
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Here, we show that the p53-related gene p73, encoding a proapoptotic protein that is linked to chemosensitivity in many settings, is upregulated through a novel epigenetic mechanism in both human and murine models of BRCA1 -associated ovarian carcinoma .
20807817 2010
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line.
11056686 2000
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
This study suggests that BRCA1 protein is a prognostic marker in sporadic OC patients with minimal RD.
21368065 2011
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Routine germline BRCA1 and BRCA2 testing in patients with ovarian carcinoma : analysis of the Scottish real-life experience.
29460478 2018
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Intraepithelial T cells and prognosis in ovarian carcinoma : novel associations with stage, tumor type, and BRCA1 loss.
19060844 2009
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma .
30266954 2018
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
BRCA1 is a tumor suppressor gene that is responsible for hereditary breast and ovarian carcinoma syndrome.11443609 2001
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
Biomarker
BEFREE
These findings confirm a high rate of loss of BRCA1 protein expression in sporadic OEC and suggest a role of BRCA1 in the progression of sporadic ovarian carcinoma .
16515585 2006
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1 /2 mutation carriers because of their increased risk of ovarian carcinoma .
29315498 2018
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Women with an existing breast carcinoma diagnosis who are found to carry a BRCA1 /2 mutation have a substantial risk of developing both a contralateral breast carcinoma and ovarian carcinoma .
11900216 2002
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
One mutation and three rare variants were identified in four women with no family history of breast or ovarian carcinoma whereas all women with affected first-degree relatives did not harbor BRCA1 mutations.
10951344 2000
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Germ-line mutations in the BRCA1 and BRCA2 genes confer a predisposition to breast as well as ovarian carcinoma .
9661879 1998
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
BRCA1 5382insC mutation in sporadic and familial breast and ovarian carcinoma in Scotland.9155062 1997
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
It is not yet known how frequently somatic BRCA1 mutations predispose to breast and ovarian carcinoma in the general female population.
8173065 1993
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2.
28882436 2017
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
To compare BRCA1 mutations in papillary serous carcinoma of the peritoneum and papillary serous ovarian carcinoma .
9764635 1998
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Ovarian Carcinoma
0.500
GeneticVariation
BEFREE
Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma .
30446260 2019